Atelier Lydie & Suelle: The Alchemists and the Mysterious Paintings

This story begins in a small atelier in the town of Merveille, the capital of the Adalet Kingdom, where two young twin sisters live. They study alchemy while helping their father, an alchemist, to run the atelier, and they share a common dream...

... to run the best atelier in the country.

However, there is a big gap between the reality of their abilities and their dream. They have a long way to go yet, and the days flow by while the girls' impatience only grows. On one of such days, the twins' path leads them to a certain painting.
Inside that painting, they find a mystical unknown world. A world full of various ingredients for their craft. Perhaps, this chance meeting with a mysterious painting is about to bring them drastically closer to turning their dream into reality...

The 19th main game in the Atelier franchise and third game in the Mysterious game trilogy.

The game features two main characters and changes some of the previous game's systems.
A new crafting feature, called Enchanting Agents, was added to the Synthesis system.
6 characters participate in combat, each attacker can have a support characters to help out, and you can now craft items while in combat.