Atelier Marie: The Alchemist of Salburg

Marlone, known by her nickname Marie, is attending the prestigious Royal Academy of Magic in the city of Salburg. Despite her eagerness and genuine passion for alchemy, Marie is the worst student enrolled, continually failing her exams due to her clumsiness while synthesizing. Her instructor Ingrid allows Marie one final chance to graduate, gives her a workshop of her own in Salburg. The condition is that Marie must successfully synthesize a high-quality item within five years, or she will be held back from graduation. Over the five years, Marlone operates from her workshop, fulfilling requests for the people of Salburg. She also interacts with Schia Donnerstag, a close friend who is suffering from a prolonged illness. There are multiple endings; a bad ending where Marlone fails, and multiple endings where she passes Ingrid's test with varying levels of success, with further variations depending on her relationship with Schia.

The game that started the Atelier franchise.
Has never been released outside Japan.